Hmgcs1 Cholesterol

Hmgcs1 CholesterolCholesterol: Synthesis, Metabolism, Regulation
The cholesterol page discusses the biosynthesis and functions of cholesterol and therapeutic means to intervene in hypercholesterolemia.

HMGCS1 Gene – GeneCards | HMCS1 Protein | HMCS1 Antibody
HMGCS1 (3-Hydroxy-3-Methylglutaryl-CoA Synthase 1) is a Protein Coding gene. Among its related pathways are Regulation of cholesterol biosynthesis by SREBP (SREBF) and Terpenoid backbone biosynthesis.

Cholesterol Synthesis – rpi.edu
Cholesterol synthesis: Hydroxymethylglutaryl-coenzyme A (HMG-CoA) is the precursor for cholesterol synthesis. HMG-CoA is also an intermediate on the pathway for synthesis of ketone bodies from acetyl-CoA.

HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 [ (human)]
ACBP is a transcriptional regulator of the HMGCS1 and HMGCR genes encoding rate-limiting enzymes of cholesterol synthesis pathway. Observational study of gene-disease association. (HuGE Navigator) …

Cholesterol Biosynthesis | Sigma-Aldrich
Cholesterol levels in the body come from two sources, dietary intake and biosynthesis. The majority of cholesterol utilized by healthy adults is synthesized in the liver, which produces ~70% of the total daily cholesterol requirement (~1 gram).

HMGCS1: 3-hydroxy-3-methylglutaryl-CoA synthase 1
GoPubMed lists recent and important papers and reviews for 3-hydroxy-3-methylglutaryl-CoA synthase 1(HMGCS1) … as well as increased expression of target genes of cholesterol synthesis (Hmgcs1 and Hmgcr) and fatty acid synthesis (Acc1 and Fas); …

Transcriptional regulation of HMG-CoA synthase and HMG-CoA …
… (HMGCS1). As shown by promoter-reporter assays ACBP represses the HNF-4alpha-induced activity of a 617bp HMGCS1 promoter fragment by approximately 80% in HepG2 cells as well as in non-endodermal HeLa cells devoid of HNF … Cholesterol; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent;

Cholesterol metabolism, transport, and hepatic regulation …
Selective aspects of cholesterol metabolism in dairy cows have been a matter of intense investigation. … 3-Hydroxy-3-methylglutaryl-CoA reductase and HMGCS1 are key enzymes of the cholesterol biosynthetic pathway and act as rate-controlling steps, …

Hydroxymethylglutaryl-CoA synthase – Wikipedia
HMGCS1: Alt. symbols: HMGCS: Entrez: 3157: HUGO: 5007: OMIM: 142940: RefSeq: … Hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase EC 2.3.3.10 is an enzyme which catalyzes the reaction in which Acetyl-CoA condenses with acetoacetyl-CoA to … HMG-CoA is an intermediate in both cholesterol …

Cholesterol Synthesis – Biochemistry of Lipids …
Cholesterol synthesis is also energetically expensive, … Cytosolic HMGCS1 synthesises mevalonic acid for cholesterol synthesis, whereas the related mitochondrial HMGCS2 produces HMG-CoA for ketogenesis and stimulates fatty acid oxidation.

MicroRNA Regulation of Cholesterol Metabolism
Disruption of cellular cholesterol balance results in pathologic processes including atherosclerosis, metabolic syndrome, type II diabetes and Alzheimer's disease. Maintenance of cholesterol homeostasis requires constant metabolic adjustment, achieved partly through the fine regulation of the …

PLOS ONE: Response of the Cholesterol Metabolism to a …
Response of the Cholesterol Metabolism to a Negative Energy Balance in Dairy Cows Depends on the … the VLDL secretion is impaired despite an upregulation of the rate-controlling key enzymes for cholesterol biosynthesis, HMGCR and HMGCS1, and the sterol synthesis stimulating gene …

PDF Hepatic SREBP-2 and cholesterol biosynthesis are regulated …
Hepatic SREBP-2 and cholesterol biosynthesis are regulated by FoxO3 and Sirt6 . Rongya Tao1, Xiwen Xiong1, … Cholesterol homeostasis is crucial for cellular function and organismal health. … analyzed SREBP-2 proteins and Hmgcr and Hmgcs1 mRNAs in the liver of control and LKOT6

Knockout of mouse Cyp3a gene enhances synthesis of …
Binding of SREBP-2 to the Hmgcs1 gene promoter was more abundant in the livers of Cyp3a −/ … Cholesterol has multifunctional roles as a component of cellular membranes and a precursor of biological molecules such as steroid hormones, oxysterols …

Cholesterol efflux in megakaryocyte progenitors suppresses …
In the bone marrow, HDL removes cholesterol from megakaryocyte progenitor cells in a process requiring the cholesterol … Cholesterol efflux in megakaryocyte progenitors suppresses platelet production and … expression of the cholesterol-responsive genes Ldlr and Hmgcs1 was …

HMGCR Gene – GeneCards | HMDH Protein | HMDH Antibody
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase.

cholesterol biosynthetic pathwayRat Genome Database
CHOLESTEROL BIOSYNTHETIC PATHWAY (PW:0000454) View Ontology Report Description The study of cholesterol spans decades of research and has garnered several Nobel prizes.

PDF Cholesterol biosynthesis and ER stress in peroxisome …
Cholesterol biosynthesis and ER stress in peroxisome deficiency Phyllis L. Fausta, Werner J. Kovacsb,c,* … (HMGCS1) are encoded by a single gene. HMGCR catalyzes the rate-limiting reaction of isoprenoid biosynthesis and is localized

High fat plus high cholesterol diet lead to hepatic …
High fat plus high cholesterol diet lead to hepatic steatosis in zebrafish larvae: a novel model for screening anti-hepatic steatosis drugs

Cholesterol metabolism, transport, and hepatic regulation …
in cholesterol synthesis (HMGCS1, and SREBF-2, HMGCR) markedly increased from wk 3 a.p. to wk 1 p.p., whereas SREBF-1 was downregulated. The ex-pression of ABCA1 increased from wk 3 a.p. to wk 1 p.p., whereas ABCG1 was increased in wk 14 p.p.

MicroRNA-223 coordinates cholesterol homeostasis
Significance. Results from this study represent a breakthrough in our understanding of posttranscriptional control of cholesterol metabolism and how microRNAs (miRNAs) are at the heart of cholesterol regulatory circuitry and homeostasis.

HNRNPA1 regulates HMGCR alternative splicing and modulates …
Statins are a class of cholesterol-lowering drugs that competitively inhibit 3-hydroxy-3-methylglutaryl-Coenzyme A reductase … (PTBP1), which we have shown to mediate changes in alternative splicing of HMGCS1, MVK, LDLR and PCSK9, but not HMGCR .

HMG-CoA reductase – Wikipedia
HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase, officially abbreviated HMGCR) … If cholesterol levels rise, proteolytic cleavage of SREBP from the membrane ceases and any proteins in the nucleus are quickly degraded.

Lipoprotein Signaling & Cholesterol Metabolism PCR Array
Lipoprotein Signaling & Cholesterol Metabolism PCR Array. … Cholesterol Biosynthesis: ACAA2, CNBP, CYB5R3, CYP51A1, DHCR24, DHCR7, FDFT1, FDPS, HMGCR, HMGCS1, HMGCS2, IDI1, IDI2, MVD, MVK, NPC1L1, NSDHL, PMVK, PRKAA1, PRKAA2, PRKAG2, TM7SF2.

PLOS ONE: Small Interfering RNA against Transcription …
Our data also showed significant increase in the level of HMGCR, HMGCS1 and IDI1 (cholesterol synthesis) and INSIG1, and CYP27B1 (cholesterol homeostasis) genes at both transcriptional (real time PCR) and translational levels (western blot analysis).

PDF CO Alternative splicing in the regulation of cholesterol …
HMG-CoA synthase 1 (HMGCS1) and mevalonate kinase (MVK) as well as key regulators of cholesterol … regulating the cholesterol biosynthesis and uptake pathways, and that it functions in conjunction with sterol response element binding protein (SREBP)-

Mutation of 3-Hydroxy-3-Methylglutaryl CoA Synthase I …
Introduction. Cholesterol is an important component of cell membranes in animals, where it organizes lipid-rich microdomains and influences membrane fluidity and permeability.

HMGCS1 (human) – phosphosite.org
HMGCS1 This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. … Biological Process: cholesterol biosynthetic process Reference #: Q01581 (UniProtKB) …

Controlling Cholesterol Synthesis beyond 3-Hydroxy-3 …
Abstract. 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the target of the statins, important drugs that lower blood cholesterol levels and treat cardiovascular disease.

Oncogene – Inhibition of cholesterol metabolism underlies …
Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine … Furthermore, we could recapitulate the effects of AKTi on CQ toxicity by knocking down the expression of HMGCS1 or … Cholesterol depletion by AKTi sensitises lysosomes to CQ-induced …

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