Cyp11a1 Cholesterol

Cyp11a1 CholesterolCholesterol side-chain cleavage enzyme – Wikipedia
Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage. P450scc is a mitochondrial enzyme that catalyzes conversion of cholesterol to pregnenolone.

CYP11A1 – Cholesterol side-chain cleavage enzyme …
Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone.

Cholesterol desmolase | definition of Cholesterol …
CYP11A1 A gene on chromosome 15q23-q24 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

P450scc | definition of P450scc by Medical dictionary
CYP11A1 A gene on chromosome 15q23-q24 that encodes a member of the cytochrome P450 superfamily of enzymes, which catalyse reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

CYP11A1 recombinant protein :: Cholesterol side-chain …
Buy CYP11A1 recombinant protein, Cholesterol side-chain cleavage enzyme Recombinant Protein (MBS948952) product datasheet at MyBioSource, Recombinant Proteins

More OMIM information for CYP11A1
The cholesterol side-chain cleavage enzyme (P450scc; EC 1.14.15.6), encoded by the CYP11A1 gene, initiates steroidogenesis by converting cholesterol to pregnenolone.

CYP11A1 cytochrome P450, family 11, subfamily A …
Gene ID: 1583, updated on 5-Feb-2017. Summary. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids.

Novel activities of CYP11A1 and their potential …
CYP11A1, found only in vertebrates, catalyzes the first step of steroidogenesis where cholesterol is converted to pregnenolone. The purified enzyme, also conver

Steroidogenic acute regulatory protein – Wikipedia
The steroidogenic acute regulatory protein, commonly referred to as StAR (STARD1), is a transport protein that regulates cholesterol transfer within the mitochondria, which is the rate-limiting step in the production of steroid hormones.

CYP11A1 Gene – GeneCards | CP11A Protein | CP11A Antibody
Complete information for CYP11A1 gene (Protein Coding), Cytochrome P450 Family 11 Subfamily A Member 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards – The Human Gene Compendium

View Article – ARVO Journals
To View More… Purchase this article with an account. or. … (CYP11A1), which catalyzes the … Similar levels of Preg and 24-OH in the retina suggest approximately equal contribution of CYP46A1 and CYP11A1 to cholesterol metabolism in retinal neurons.

CYP11A1 gene – Genetics Home Reference
CYP11A1 gene cytochrome P450 family 11 subfamily A member 1. Open All Close All. The information on this page was … This protein localizes to the mitochondrial inner membrane and catalyzes the conversion of cholesterol to pregnenolone, …

Structural Basis for Three-step Sequential Catalysis by …
Structural Basis for Three-step Sequential Catalysis by the Cholesterol Side Chain Cleavage Enzyme CYP11A1* … not accumulate during the conversion of cholesterol to pregnenolone and bind much more tightly to CYP11A1 than cholesterol, suggesting that …

CYP11A1 (human) – phosphosite.org
CYP11A1 Catalyzes the side-chain cleavage reaction of cholesterol to pregnenolone. Defects in CYP11A1 are the cause of adrenal insufficiency congenital with 46,XY sex reversal (AICSR).

Early steps in steroidogenesis: intracellular cholesterol …
Cholesterol esters and "free" cholesterol are enzymatically interconverted in lipid droplets. Cholesterol transport to the cholesterol-poor outer mitochondrial membrane (OMM) appears to involve … especially the CYP11A1 gene encoding the enzymatically rate-limiting enzyme P450scc (190, 191).

Molecular cloning and expression patterns of the …
Molecular cloning and expression patterns of the cholesterol side chain cleavage enzyme (CYP11A1) gene during the reproductive cycle in goose (Anas cygnoides)

A simple and rapid method to measure cholesterol binding …
Nonspecific cholesterol binding to CYP11A1 was 28%. Previous Section Next Section. DISCUSSION. In this report, we describe a simple and rapid method to measure cholesterol binding. Three P450 enzymes …

Anti-CYP11A1 antibody (ab75497) | Abcam
Cholesterol monooxygenase (side chain cleaving) antibody; … Anti-CYP11A1 antibody (ab75497) at 1 µg/ml + HeLa cell lysate at 10 µg Secondary HRP conjugated anti-Rabbit IgG at 1/50000 dilution Predicted band size : 60 kDa Observed band size : 60 kDa.

P450scc: Cytochrome P450, family 11, subfamily A …
Here we report that pregnenolone, which is produced from cholesterol by the steroidogenic enzyme Cyp11a1 (cholesterol side-chain cleavage enzyme, P450scc), functions in promoting cell migration during epiboly.

Severe Combined Adrenal and Gonadal Deficiency Caused by …
Context: Mitochondrial cytochrome P450scc converts cholesterol to pregnenolone in all steroidogenic tissues. Although progesterone production from the fetally-derived placenta is necessary to maintain pregnancy to term, four patients with mutations in the gene encoding P450scc (CYP11A1), have …

Evolutionary Origin of the Mitochondrial Cholesterol …
Introduction. The rate-limiting step in steroid biosynthesis is the transport of the sole substrate cholesterol from intracellular stores into mitochondria where cholesterol is metabolized by the inner mitochondrial membrane enzyme cytochrome P450 family 11 subfamily A polypeptide 1 (CYP11A1) to …

Spatial Distribution of the Pathways of Cholesterol …
Spatial Distribution of the Pathways of Cholesterol Homeostasis in Human Retina. Wenchao … surface of the eye and one of the few human organs whose cholesterol maintenance is still … expression of HMGCR and LDLR; CYP27A1, CYP46A1 and CYP11A1, cytochromes P450 that metabolize …

Cholesterol – ICGEB
Cholesterol Last modified: Tue Jul 6 10:51:09 BST 2004 Steroid carbon nomenclature. Trivial names: Cholesterol; … Enzyme: P450scc (cholesterol side-chain cleavage), CYP11A1 EC 1.14.15.6. CPM1_BOVIN CPM1_HUMAN CPM1_PIG CPM1_RAT CPM1_ONCMY. Substrate Pathway: Cholesterol 7-Hydroxycholesterol

Cholesterol, Steroid and Isoprenoid Biosynthesis
Figure 4. Steroid biosynthesis. Cholesterol is converted to pregnenolone by CYP11A1, and subsequent enzymes yield the mineralocorticoid aldosterone (top row), the glucocorticoid cortisol (second row), or precursors of active androgens and oestrogens (third row).

Cholesterol-metabolizing Cytochromes P450
CYP27A1 is a ubiquitously expressed mitochondrial P450 that metabolizes cholesterol to 27-hydroxycholesterol. CYP11A1 also resides in mitochondria but is expressed mainly in steroidogenic tissues, where it catalyzes the conversion of cholesterol to pregnenolone.

CYP11A1 | SelfDecode | Genome Analysis
cyp11a1 causes drug metabolism and the creation of cholesterol, steroids, and other lipids. Assists with the conversion of cholesterol to pregnenolone.R

PDF Partial Defect in the Cholesterol Side-Chain Cleavage …
Partial Defect in the Cholesterol Side-Chain Cleavage Enzyme P450scc (CYP11A1) Resembling Nonclassic Congenital Lipoid Adrenal Hyperplasia Taninee Sahakitrungruang,* Meng Kian Tee,* Piers R. Blackett,

CYP11A1 | Cancer Genetics Web
CYP11A1; cytochrome P450, family 11, subfamily A, polypeptide 1: Aliases: CYP11A, CYPXIA1, P450SCC : Location: … cholesterol side-chain cleavage enzyme, mitochondrial HPRD: Source: NCBI Accessed: 21 August, 2015: Ontology: What does this gene/protein do?

Identification of a Dynamic Mitochondrial Protein Complex …
Complex Driving Cholesterol Import, Trafficking, and Metabolism to Steroid Hormones Malena B. Rone, Andrew S. Midzak, Leeyah Issop, … nel the flow of cholesterol into IMM, where CYP11A1 is located, remains unknown. Currently this process is pro-

Expression of zebrafish cyp11a1 as a maternal transcript …
Cyp11a1 (P450scc, cholesterol side-chain cleavage enzyme) is the first enzyme for the synthesis of all steroid hormones. The regulation of steroid synthesis has been extensively investigated, except during embryogenesis.

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